Description

tert-Butyl 5-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate is a protected intermediate of significant value in advanced organic synthesis. This compound matters for its role as a versatile building block in the development of complex pharmaceutical molecules and fine chemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those with quinoline-based scaffolds.
• Organic Synthesis Building Block: Used for constructing complex heterocyclic compounds in medicinal chemistry and material science research.
• Agrochemical Research: Serves as a precursor in the development of new active ingredients for crop protection.
• Chemical Biology Probe Development: Utilized in the creation of molecular tools for studying biological pathways.
• Process Chemistry: Employed in route scouting and scale-up for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 5-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
CAS No.	497068-73-2
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	1-Boc-5-hydroxy-1,2,3,4-tetrahydroquinoline; 5-Hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-N-Boc-5-hydroxy-1,2,3,4-tetrahydroquinoline; 5-Hydroxy-1,2,3,4-tetrahydroquinoline N-Boc derivative; 1-(tert-Butoxycarbonyl)-5-hydroxy-1,2,3,4-tetrahydroquinoline; 5-Hydroxy-N-Boc-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.