Description

Fmoc-n-Me-Eda(n-Me).Hcl is a specialized, protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing a modified ethylenediamine scaffold with N-methylation, enabling the synthesis of peptides with enhanced metabolic stability and altered conformational properties. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating N-methylated diamino acid structures into peptide chains.
• Peptidomimetic Drug Discovery: For creating peptide analogs with improved bioavailability and resistance to enzymatic degradation.
• Combinatorial Chemistry Libraries: Used in the generation of diverse compound libraries for high-throughput screening.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: A tool compound for studying protein-protein interactions and modulating biological pathways.
• Custom Oligomer Synthesis: For the production of specialized non-natural oligomers and foldamers.

Basic Information

Product Name	Fmoc-n-Me-Eda(n-Me).Hcl
CAS No.	496946-83-9
Molecular Formula	C₂₁H₂₅N₃O₄ • HCl
Molecular Weight	419.90 g/mol (Free base: 383.44 g/mol)
Synonyms	Fmoc-N-Me-EDA(N-Me)-OH•HCl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-methyl-N-methyl-1,2-ethanediamine Hydrochloride; Fmoc-N-methyl-ethylenediamine(N-methyl) hydrochloride; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(methylamino)-N-methylethanamine Hydrochloride; Fmoc-N(Me)-EDA-N(Me)-OH•HCl; Nα-Fmoc-N'-methyl-N-methyl-ethylenediamine hydrochloride; Protected N-methylated ethylenediamine derivative; Fmoc-Me-EDA(Me)-OH•HCl
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Eda(n-Me).Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, to ensure consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.