Description

1H-Indene-1-Acetic Acid, 2,3-Dihydro-5-Methoxy-, (1S)- is a chiral, non-racemic organic compound belonging to the indene acetic acid derivative class. This specific stereoisomer is of significant value as a key synthetic intermediate and building block in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. The compound's defined stereochemistry and functional groups make it a critical precursor for creating molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery programs.
• Fine Chemical Production: Acts as a specialized intermediate for the manufacture of high-value, low-volume fine chemicals and advanced materials.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in laboratory settings.

Basic Information

Product Name	1H-Indene-1-Acetic Acid, 2,3-Dihydro-5-Methoxy-, (1S)-
CAS No.	496061-78-0
Molecular Formula	C₁₂H₁₄O₃
Molecular Weight	206.24 g/mol
Synonyms	(1S)-2,3-Dihydro-5-methoxy-1H-indene-1-acetic acid; (S)-2,3-Dihydro-5-methoxy-1H-indene-1-acetic acid; (-)-2,3-Dihydro-5-methoxy-1H-indene-1-acetic acid; (1S)-5-Methoxyindan-1-ylacetic acid; 5-Methoxyindan-1-acetic acid, (S)-; 1H-Indene-1-acetic acid, 2,3-dihydro-5-methoxy-, (1S)-; (S)-5-Methoxy-2,3-dihydro-1H-indene-1-acetic acid
EINECS	Contact for details

Quality Control

Our production of 1H-Indene-1-Acetic Acid, 2,3-Dihydro-5-Methoxy-, (1S)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity determination, to confirm identity and specification compliance. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, enantiomeric excess (ee), and impurity profiles. We support cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.