Description

8-Cyano-4-Hydroxy-Quinoline-2-Carboxylic Acid Methyl Ester is a high-value, multi-functional quinoline derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique molecular structure, featuring cyano, hydroxy, and ester functional groups, makes it an essential building block for constructing complex heterocyclic systems. This compound is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of quinoline-based drug candidates, particularly for antimicrobial, anticancer, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the quinoline scaffold.
• Material Science: Serves as a monomer or functional additive in the research of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Employed as a versatile building block for creating complex heterocyclic compounds in medicinal and combinatorial chemistry.
• Dye & Pigment Industry: Acts as an intermediate in the synthesis of specialized quinoline-based dyes and fluorescent markers.
• Academic & Contract Research: A valuable reagent for methodological studies and novel reaction pathway exploration in university and CRO laboratories.

Basic Information

Product Name	8-Cyano-4-Hydroxy-Quinoline-2-Carboxylic Acid Methyl Ester
CAS No.	495407-19-7
Molecular Formula	C₁₃H₈N₂O₃
Molecular Weight	240.22 g/mol
Synonyms	Methyl 8-cyano-4-hydroxyquinoline-2-carboxylate; 4-Hydroxy-8-cyanoquinoline-2-carboxylic acid methyl ester; 2-Quinolinecarboxylic acid, 8-cyano-4-hydroxy-, methyl ester; 8-Cyano-4-hydroxy-2-quinolinecarboxylic acid methyl ester; 495407-19-7; Methyl 4-hydroxy-8-cyanoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of 8-Cyano-4-Hydroxy-Quinoline-2-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR, IR) to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.