Description

1-(2,3-Diacetyl-5-Tosyl-α-D-Arabinofuranosyl)-2-Nitroimidazole Precursor For [18F]Faza is a critical, high-purity synthetic intermediate specifically designed for the production of the Positron Emission Tomography (PET) imaging agent [18F]Faza. This compound matters because it enables the reliable and efficient radiolabeling process essential for creating a diagnostic tracer used in oncology research. Pharmaceutical manufacturers, radiopharmaceutical CDMOs, and advanced research institutions developing hypoxia-targeting PET imaging agents are the primary users of this precursor. Its consistent quality is paramount for ensuring the reproducibility and efficacy of the final radiopharmaceutical product.

Application

• Primary Precursor for [18F]Faza Synthesis: The essential starting material for the nucleophilic fluorination reaction to produce the PET tracer [18F]Faza (Fluorine-18 labeled fluoroazomycin arabinoside).
• Oncology Research & Drug Development: Used in preclinical and clinical research to develop and validate PET imaging protocols for detecting tumor hypoxia, a key factor in cancer progression and treatment resistance.
• Radiopharmaceutical Manufacturing: Serves as a key building block in GMP-compliant production lines within specialized radiopharmacies and contract manufacturing organizations for clinical-grade tracer supply.
• Molecular Imaging Agent Development: A vital component in the research and development of next-generation diagnostic imaging agents targeting hypoxic tissues.
• Academic & Institutional Research: Utilized in university and hospital research laboratories studying hypoxia mechanisms, tumor biology, and the efficacy of radiotherapy and chemotherapy.

Basic Information

Product Name	1-(2,3-Diacetyl-5-Tosyl-α-D-Arabinofuranosyl)-2-Nitroimidazole Precursor For [18F]Faza
CAS No.	494775-35-8
Molecular Formula	C20H23N3O9S
Molecular Weight	481.48 g/mol
Synonyms	FAZA Precursor; [18F]FAZA Precursor; 1-(2,3-Di-O-acetyl-5-O-tosyl-α-D-arabinofuranosyl)-2-nitroimidazole; 2-Nitroimidazole Arabinoside Precursor; Fluoroazomycin Arabinoside Precursor; Hypoxia Imaging Agent Precursor; PET Tracer Building Block; 1-α-D-(2,3-Di-O-acetyl-5-O-p-tolylsulfonyl-arabinofuranosyl)-2-nitroimidazole
EINECS	Contact for details

Quality Control

This precursor is manufactured under strict quality control protocols to meet the exacting standards required for radiopharmaceutical synthesis. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure structural identity and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and residual solvent levels. Our quality system is designed to support applications in research and GMP environments, ensuring reliable and reproducible performance in your fluorination reactions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be sealed under an inert atmosphere (e.g., argon or nitrogen) after opening and allowed to equilibrate to room temperature before opening to minimize moisture ingress. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.