Description

(S)-3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid Hydrochloride is a high-purity, single-enantiomer chiral building block essential for advanced pharmaceutical research and development. Its core value lies in providing a structurally defined, trifluoromethyl-substituted phenylalanine derivative, a privileged scaffold in medicinal chemistry for modulating drug potency, metabolic stability, and bioavailability. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethyl group and chiral center on biological activity.
• Peptidomimetic Development: Serves as a non-natural amino acid analog for constructing peptide-based therapeutics with enhanced stability and receptor selectivity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of enantiomerically pure pharmaceuticals.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Research: Potential intermediate in the development of chiral agrochemicals, such as herbicides and fungicides, where specific stereochemistry is crucial for activity.

Basic Information

Product Name	(S)-3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid Hydrochloride
CAS No.	490034-86-1
Molecular Formula	C10H11F3NO2 • HCl
Molecular Weight	269.65 (Free base) / 306.11 (HCl salt)
Synonyms	(S)-3-Amino-3-(3-(trifluoromethyl)phenyl)propanoic acid hydrochloride; (S)-3-Amino-3-(α,α,α-trifluoro-m-tolyl)propionic acid hydrochloride; (S)-3-Amino-3-(3-trifluoromethylphenyl)propionic acid HCl; (S)-β-Amino-3-(trifluoromethyl)hydrocinnamic acid hydrochloride; (S)-3-(3-Trifluoromethylphenyl)-β-alanine hydrochloride; (S)-3-(3-Trifluoromethylphenyl)-3-aminopropanoic acid hydrochloride; (S)-ATPA HCl; L-3-Amino-3-(3-trifluoromethylphenyl)propanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard pharmacopeial methods for identity, purity, and impurity profiling. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for assay, chiral purity, related substances, residual solvents, and heavy metals. Our quality commitment ensures material suitable for cGMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.