Description

Fmoc-L-2,3-Diaminopropionic Acid Hydrochloride is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for the controlled introduction of the unique 2,3-diaminopropionic acid residue into peptide chains, enabling the creation of complex molecular architectures. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: For the synthesis of peptide drug candidates, including constrained peptides and those with modified backbones.
• Bioconjugation and Linker Chemistry: Utilizes the orthogonal protection (Fmoc on α-amine) and the free side-chain amine for creating peptide-drug conjugates or attaching labels and tags.
• Chemical Biology Probes: Incorporation into peptides used to study protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Material Science: Synthesis of peptide-based biomaterials, hydrogels, and surface coatings where precise amino acid sequences are required.
• Reference Standard Production: Serves as a high-purity raw material for manufacturing certified reference standards (CRS) and analytical controls.

Basic Information

Product Name	Fmoc-L-2,3-Diaminopropionic Acid Hydrochloride
CAS No.	487027-89-4
Molecular Formula	C₁₈H₁₉N₂O₄·HCl
Molecular Weight	354.81 g/mol
Synonyms	Fmoc-Dap-OH·HCl; N-α-Fmoc-L-2,3-diaminopropionic acid hydrochloride; Fmoc-L-Dap-OH·HCl; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-aminopropanoic acid hydrochloride; Fmoc-2,3-diaminopropionic acid HCl; N-Fmoc-L-2,3-diaminopropanoic acid hydrochloride; Fmoc-L-β-diaminopropionate HCl
EINECS	Contact for details

Quality Control

Our Fmoc-L-2,3-Diaminopropionic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements of peptide synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.