Description

1-(4-Bromo-2,5-Difluorophenylsulfonyl)Pyrrolidine is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its unique sulfonamide-linked pyrrolidine and halogenated aryl structure, which is critical for modulating biological activity and physicochemical properties in drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting kinase inhibition and G-protein-coupled receptors (GPCRs).
• Agrochemical Research: Serves as a building block for developing new-generation herbicides and fungicides with enhanced efficacy.
• Material Science: Used in the research and development of specialty polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or linker in the design of activity-based probes and protein inhibitors.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including cross-coupling and sulfonylation reactions.

Basic Information

Product Name	1-(4-Bromo-2,5-Difluorophenylsulfonyl)Pyrrolidine
CAS No.	486422-45-1
Molecular Formula	C10H10BrF2NO2S
Molecular Weight	338.16 g/mol
Synonyms	Pyrrolidine, 1-[(4-bromo-2,5-difluorophenyl)sulfonyl]-; 1-(4-Bromo-2,5-difluorobenzenesulfonyl)pyrrolidine; 4-Bromo-2,5-difluoro-N-(pyrrolidin-1-yl)sulfonyl)aniline; 486422-45-1; N-(4-Bromo-2,5-difluorophenylsulfonyl)pyrrolidine; 1-(4-Bromo-2,5-difluorophenyl)sulfonylpyrrolidine
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2,5-Difluorophenylsulfonyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.