Description

Spiro[Bicyclo[2.2.1]Heptane-2,2-Oxirane], 7,7-Dimethyl-, (1R,2S,4R)- (9Ci) is a high-purity, stereochemically defined spirocyclic epoxide building block of significant interest in advanced organic synthesis. Its unique rigid, three-dimensional structure makes it a valuable precursor for constructing complex molecular architectures with precise spatial orientation. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel chiral ligands or catalysts.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Asymmetric Catalysis: Used in the development and synthesis of novel chiral ligands, auxiliaries, and organocatalysts for enantioselective transformations.
• Agrochemical Research: Acts as a building block for creating new chiral molecules with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science Monomer: Potential use as a specialty monomer for creating polymers with unique thermal and mechanical properties due to its rigid, spiro-fused backbone.
• Academic & R&D: Employed in fundamental research exploring new reaction methodologies, cycloaddition chemistry, and the synthesis of complex natural product analogs.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of high-value, complex fine chemicals and specialty compounds requiring specific stereochemistry.

Basic Information

Product Name	Spiro[Bicyclo[2.2.1]Heptane-2,2-Oxirane], 7,7-Dimethyl-, (1R,2S,4R)- (9Ci)
CAS No.	482288-55-1
Molecular Formula	C9H14O
Molecular Weight	138.21 g/mol
Synonyms	(1R,2S,4R)-7,7-Dimethylspiro[bicyclo[2.2.1]heptane-2,2'-oxirane]; (1R,2S,4R)-7,7-Dimethyl-2-oxaspiro[bicyclo[2.2.1]heptane-2,2'-oxirane]; (-)-7,7-Dimethyl-2-oxaspiro[bicyclo[2.2.1]heptane-2,2'-oxirane]; Chiral Spirocyclic Epoxide; 7,7-Dimethyl-2-oxaspiro[bicyclo[2.2.1]heptane-2,2'-oxirane] (enantiomer); Spiro[norbornane-2,2'-oxirane], 7,7-dimethyl-, (1R,2S,4R)-; Bicyclo[2.2.1]heptane, 7,7-dimethyl-2,2-epoxy-, (1R,2S,4R)-
EINECS	Contact for details

Quality Control

Our production of Spiro[Bicyclo[2.2.1]Heptane-2,2-Oxirane], 7,7-Dimethyl-, (1R,2S,4R)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is fully characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to moisture and strong acids/bases; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Optical Rotation [α]	Specific value provided on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.