Description

Ruthenium, [1,3-Bis(2,4,6-Trimethylphenyl)-2-imidazolidinylidene]dichloro[[2-(1-methylethoxy-κO)[1,1'-biphenyl]-3-yl]methylene-κC]-, (SP-5-41)- is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and selectivity in challenging cross-metathesis and ring-closing metathesis (RCM) reactions. It is a critical tool for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the efficient synthesis of complex molecules and polymers. The CAS number for this compound is 478944-19-3.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key ring-closing metathesis (RCM) and cross-metathesis steps in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel, complex molecules for crop protection agents and herbicides.
• Advanced Polymer & Material Science: Facilitating ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET) for creating specialty polymers, elastomers, and functional materials.
• Fine Chemical & Fragrance Manufacturing: Applied in the synthesis of complex olefinic structures that are difficult to access via traditional methods.
• Academic & Industrial R&D: A staple catalyst for methodology development and exploring new synthetic routes in organic chemistry laboratories worldwide.
• Synthesis of Natural Products & Complex Macrocycles: Ideal for constructing large, strained rings present in many natural products and macrocyclic compounds.

Basic Information

Item	Detail
Product Name	Ruthenium, [1,3-Bis(2,4,6-Trimethylphenyl)-2-imidazolidinylidene]dichloro[[2-(1-methylethoxy-κO)[1,1'-biphenyl]-3-yl]methylene-κC]-, (SP-5-41)-
CAS No.	478944-19-3
Molecular Formula	C₄₃H₅₁Cl₂N₂ORu
Molecular Weight	822.92 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium; HG II; GH II; RuCl₂(IMesH₂)(CH-2-O-iPr-C₆H₄); [RuCl₂(IMes)(CH-2-O-iPr-C₆H₄)]
EINECS	Contact for details

Quality Control

Every batch of our Grubbs-Hoveyda II Catalyst is manufactured and tested under stringent quality protocols to ensure high catalytic activity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and performance characteristics. Our quality systems are designed to meet the exacting standards of GMP and ISO-guided environments for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is moisture-sensitive (hygroscopic) and easily oxidized; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Dark green to purple crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.