Description

D-[5,6-13C2]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 5th and 6th carbon positions. This precise labeling is critical for advanced metabolic research, enabling accurate tracing and quantification of glucose utilization and metabolic flux in complex biological systems. It is an essential tool for researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors conducting tracer studies, metabolic pathway analysis, and drug metabolism investigations.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic reaction rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in studies to trace the metabolic fate of new chemical entities and understand their impact on host metabolism.
• Biomarker Discovery & Clinical Diagnostics: Serves as a standard in mass spectrometry-based assays for the accurate measurement of glucose metabolism-related biomarkers.
• Nutritional & Metabolic Disease Research: Applied in studies investigating insulin resistance, diabetes, and cancer metabolism to elucidate pathway dysregulation.
• Stable Isotope Probing (SIP): Utilized in environmental and microbiological research to track microbial assimilation of carbon in complex communities.
• NMR Spectroscopy: Provides a sensitive probe for structural and dynamic studies of metabolic processes using Nuclear Magnetic Resonance.
• Internal Standard for LC-MS/MS: Acts as a high-purity internal standard for the precise quantification of glucose and related metabolites in complex biological matrices.

Basic Information

Product Name	D-[5,6-13C2]Glucose
CAS No.	478529-46-3
Molecular Formula	C6H12O6 (13C2 labeled)
Molecular Weight	182.15 (for 13C2 labeled form)
Synonyms	D-Glucose-5,6-13C2; (5,6-13C2)-D-Glucose; D-(+)-Glucose-5,6-13C2; 13C2-Glucose; Isotopically Labeled D-Glucose; D-Glucose (13C2, 5,6); 6-(Hydroxymethyl)oxane-2,3,4,5-tetrol-5,6-13C2; D-Glucopyranose-5,6-13C2
EINECS	Contact for details

Quality Control

Our stable isotope-labeled products are manufactured and tested under stringent quality systems. Each batch of D-[5,6-13C2]Glucose is subjected to rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic enrichment, and purity. Certificates of Analysis (COA) are provided, detailing batch-specific results for isotopic purity, chemical purity, and other critical parameters to ensure data integrity for your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (5,6-13C2)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.