Description

2-(4-[(4-Fluorophenyl)Sulfonyl]Piperazino)-4,8-Dimethylquinoline is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound matters for its role as a key synthetic building block in the research and development of novel therapeutic agents, particularly those targeting central nervous system and oncological pathways. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need it to support their discovery and process development programs. Its defined structure and purity are critical for ensuring reproducible results in complex synthetic sequences.

Application

• Primary use as a pharmaceutical intermediate in the synthesis of potential drug candidates.
• Key building block for research into kinase inhibitors and other targeted small-molecule therapies.
• Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Precursor in the development of compounds for central nervous system (CNS) disorders.
• Used in process chemistry for route scouting and optimization at pilot scales.
• Reference standard for analytical method development and quality control in API manufacturing.
• Starting material for custom synthesis services in contract research and manufacturing (CRAM).

Basic Information

Product Name	2-(4-[(4-Fluorophenyl)Sulfonyl]Piperazino)-4,8-Dimethylquinoline
CAS No.	478081-69-5
Molecular Formula	C21H22FN3O2S
Molecular Weight	399.48 g/mol
Synonyms	4,8-Dimethyl-2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]quinoline; 2-[4-[(4-Fluorophenyl)sulfonyl]piperazin-1-yl]-4,8-dimethylquinoline; 1-(4,8-Dimethylquinolin-2-yl)-4-(4-fluorophenyl)sulfonylpiperazine; 478081-69-5; 4,8-Dimethyl-2-(4-(4-fluorophenyl)sulfonylpiperazin-1-yl)quinoline; 2-(4-(4-Fluorophenylsulfonyl)piperazino)-4,8-dimethylquinoline
EINECS	Contact for details

Quality Control

Our 2-(4-[(4-Fluorophenyl)Sulfonyl]Piperazino)-4,8-Dimethylquinoline is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.