Description

(1S,2S)-trans-1,2-Cyclopentanediamine Dihydrochloride is a high-purity chiral diamine salt, a crucial building block in asymmetric synthesis and pharmaceutical development. Its value lies in its rigid, trans-configured cyclopentane backbone, which provides excellent stereochemical control for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for active pharmaceutical ingredients (APIs), ligands, and catalysts.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of enantiomerically pure drugs, particularly for central nervous system (CNS) and antiviral therapeutics.
• Asymmetric Catalyst Ligand: Used to synthesize chiral ligands for transition metal catalysis, enabling highly selective chemical transformations.
• Agrochemical Synthesis: Serves as a building block for developing chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Peptidomimetics & Bioactive Molecules: Incorporated into the design of conformationally constrained peptides and other bioactive compounds to enhance stability and receptor binding.
• Resolution Agent: Employed as a chiral resolving agent for the separation of racemic mixtures of carboxylic acids and other compounds.
• Polymer Modification: Used in the creation of specialty polymers with tailored properties, such as chiral stationary phases for chromatography.

Basic Information

Product Name	(1S,2S)-trans-1,2-Cyclopentanediamine Dihydrochloride
CAS No.	477873-22-6
Molecular Formula	C5H14Cl2N2
Molecular Weight	173.08 g/mol
Synonyms	(1S,2S)-1,2-Diaminocyclopentane Dihydrochloride; (1S,2S)-trans-1,2-Diaminocyclopentane Dihydrochloride; (1S,2S)-Cyclopentane-1,2-diamine Dihydrochloride; trans-(1S,2S)-1,2-Cyclopentanediamine Dihydrochloride; (1S,2S)-1,2-Cyclopentylenediamine Dihydrochloride; (1S,2S)-DACH Dihydrochloride; (1S,2S)-Diaminocyclopentane Dihydrochloride; (1S,2S)-DACP Dihydrochloride
EINECS	Contact for details

Quality Control

Our (1S,2S)-trans-1,2-Cyclopentanediamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.