Description

2-Fluoro-N'-Methyl-N'-[2-(Trifluoromethyl)-4-Quinazolinyl]Benzenecarbohydrazide is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinazoline and fluorinated aromatic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Oncology Research: Used in the development of potential anti-cancer agents due to the quinazoline scaffold's known biological activity.
• Medicinal Chemistry: Serves as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays and pharmacological studies.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for introducing complex fluorinated quinazoline motifs into target molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP or non-GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Fluoro-N'-Methyl-N'-[2-(Trifluoromethyl)-4-Quinazolinyl]Benzenecarbohydrazide
CAS No.	477867-52-0
Molecular Formula	C₁₇H₁₂F₄N₄O
Molecular Weight	364.30 g/mol
Synonyms	2-Fluoro-N'-methyl-N'-[2-(trifluoromethyl)quinazolin-4-yl]benzohydrazide; Benzenecarbohydrazide, 2-fluoro-N'-methyl-N'-[2-(trifluoromethyl)-4-quinazolinyl]-; 477867-52-0; 2-Fluoro-N'-methyl-N'-(2-trifluoromethylquinazolin-4-yl)benzohydrazide; 4-Quinazolinylbenzenecarbohydrazide, 2-fluoro-N'-methyl-N'-[2-(trifluoromethyl)-]; Fluorinated Quinazoline Hydrazide Derivative
EINECS	Contact for details

Quality Control

Our 2-Fluoro-N'-Methyl-N'-[2-(Trifluoromethyl)-4-Quinazolinyl]Benzenecarbohydrazide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to a quality management system to support our commitment to reliable supply for critical R&D pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from incompatible materials such as strong alkalis. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.