Description

3-Chloro-4-Fluoro-Benzamidine Hydrochloride is a high-purity organic intermediate of significant importance in modern pharmaceutical and agrochemical research. This compound serves as a critical building block for the synthesis of more complex molecules, particularly those with potential biological activity. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting enzymes where the amidine moiety acts as a bioisostere.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the halogenated benzamidine structure.
• Chemical Biology Probe Synthesis: Employed in creating molecular probes for studying biological processes and protein interactions.
• Fine Chemical Synthesis: Serves as a versatile building block for constructing complex heterocycles and specialty chemicals.
• Library Compound Generation: Utilized in combinatorial chemistry and high-throughput screening for drug discovery programs.

Basic Information

Product Name	3-Chloro-4-Fluoro-Benzamidine Hydrochloride
CAS No.	477844-52-3
Molecular Formula	C7H7ClF N2 • HCl
Molecular Weight	209.05 g/mol (Free base: 172.59 g/mol)
Synonyms	3-Chloro-4-fluorobenzamidine hydrochloride; 3-Chloro-4-fluorobenzenecarboximidamide hydrochloride; 4-Fluoro-3-chlorobenzamidine HCl; Benzenecarboximidamide, 3-chloro-4-fluoro-, hydrochloride (1:1); (3-Chloro-4-fluorophenyl)methanimidamide hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoro-Benzamidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable and traceable material for critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.