Description

3-[(4-Fluorophenyl)Sulfonyl]-1-(4-Methylphenyl)-1-Propanone CAS NO 477334-47-7 is a specialized organic sulfone compound featuring a propanone backbone with fluorophenyl and tolyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block in modern synthetic chemistry. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in therapeutic areas targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, sulfonylation processes, and as a scaffold for constructing complex molecular architectures in medicinal chemistry.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in regulatory and research laboratories.

Basic Information

Product Name	3-[(4-Fluorophenyl)Sulfonyl]-1-(4-Methylphenyl)-1-Propanone
CAS No.	477334-47-7
Molecular Formula	C₁₆H₁₅FO₃S
Molecular Weight	306.35 g/mol
Synonyms	1-(4-Methylphenyl)-3-[(4-fluorophenyl)sulfonyl]-1-propanone; 3-(4-Fluorophenylsulfonyl)-1-(p-tolyl)propan-1-one; 4-Fluoro-β-oxo-β-(p-tolyl)benzenepropanesulfonic acid sulfone; p-Tolyl 3-(4-fluorophenylsulfonyl)propyl ketone; 477334-47-7 (CAS); 3-(4-Fluorobenzenesulfonyl)-1-(4-methylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our production of 3-[(4-Fluorophenyl)Sulfonyl]-1-(4-Methylphenyl)-1-Propanone adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical applications, and we welcome audits and specific quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.