Description

Quinoline, 6-Bromo-4-[5,6-Dihydro-2-(2-Pyridinyl)-4H-Pyrrolo[1,2-B]Pyrazol-3-Yl]- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 476474-31-4. This complex heterocyclic compound is valued for its unique molecular scaffold, which is critical for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially kinase inhibitors.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex fused heterocyclic systems.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Chemical Biology: Acts as a probe or precursor for developing chemical tools to study biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• High-Value Fine Chemical Production: Integral in the multi-step synthesis of specialized, low-volume, high-cost target molecules.

Basic Information

Item	Details
Product Name	Quinoline, 6-Bromo-4-[5,6-Dihydro-2-(2-Pyridinyl)-4H-Pyrrolo[1,2-B]Pyrazol-3-Yl]-
CAS No.	476474-31-4
Molecular Formula	C19H15BrN4
Molecular Weight	379.26 g/mol
Synonyms	6-Bromo-4-(5,6-dihydro-2-(pyridin-2-yl)-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline; 476474-31-4; 6-Bromo-4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline; Quinoline, 6-bromo-4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-; 4-(6-Bromoquinolin-4-yl)-2-(pyridin-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
EINECS	Contact for details

Quality Control

Our Quinoline, 6-Bromo-4-[5,6-Dihydro-2-(2-Pyridinyl)-4H-Pyrrolo[1,2-B]Pyrazol-3-Yl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with ICH guidelines to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider using inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.