Description

Boc-Nh-Peg2-Nh-Boc CAS NO 475591-59-4 is a high-purity, bifunctional polyethylene glycol (PEG)-based linker featuring two tert-butoxycarbonyl (Boc) protecting groups. This compound is specifically engineered for the controlled synthesis and modification of peptides, proteins, and other biomolecules, offering a versatile spacer arm for conjugation chemistry. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotech industries, particularly in the development of antibody-drug conjugates (ADCs), peptide therapeutics, and advanced drug delivery systems.

Application

• Pharmaceutical Intermediate: A key reagent in the solid-phase and solution-phase synthesis of peptide-based drugs and prodrugs.
• Bioconjugation Linker: Used to create stable, hydrophilic spacers between a targeting moiety (e.g., an antibody) and a cytotoxic payload in ADC development.
• Polymer Chemistry: Serves as a functional initiator or monomer for synthesizing specialized PEG-based copolymers with controlled architectures.
• Proteomics Research: Employed in the modification and cross-linking of proteins for structural studies and assay development.
• Material Science: Utilized to functionalize surfaces and nanomaterials with biocompatible PEG layers to reduce non-specific binding and improve solubility.
• Diagnostic Reagents: Acts as a linker in the preparation of labeled probes and assay components for in vitro diagnostics.

Basic Information

Product Name	Boc-Nh-Peg2-Nh-Boc
CAS No.	475591-59-4
Molecular Formula	C₁₈H₃₆N₂O₈
Molecular Weight	408.49 g/mol
Synonyms	1,11-Bis(tert-butoxycarbonyl)-1,4,8,11-tetraazaundecane-4,8-dicarboxylic acid; 2,2'-(Ethylenedioxy)bis(ethylamine) bis-Boc derivative; N-Boc-3,6-dioxaoctane-1,8-diamine; Boc-NH-PEG2-NH-Boc; Di-Boc-protected PEG2 diamine; 1,8-Bis(Boc-amino)-3,6-dioxaoctane; tert-Butyl N-[2-[2-[2-[(tert-butoxycarbonyl)amino]ethoxy]ethoxy]ethyl]carbamate
EINECS	Contact for details

Quality Control

Our Boc-Nh-Peg2-Nh-Boc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.