Description

2-(4-Chlorophenyl)-2,2-Difluoroacetic Acid is a high-value fluorinated aromatic building block, essential for introducing the difluoroacetate moiety into complex molecular architectures. Its primary commercial significance lies in its role as a key intermediate in the synthesis of advanced pharmaceutical compounds, particularly those targeting metabolic and central nervous system disorders. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoroacetic acid group can improve efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for metabolic pathway studies and drug discovery.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-(4-Chlorophenyl)-2,2-Difluoroacetic Acid
CAS No.	475301-73-6
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	4-Chloro-α,α-difluorophenylacetic Acid; (4-Chlorophenyl)difluoroacetic Acid; 2,2-Difluoro-2-(4-chlorophenyl)acetic Acid; α,α-Difluoro-4-chlorophenylacetic Acid; p-Chloro-α,α-difluorophenylacetic Acid; Difluoro(4-chlorophenyl)acetic Acid; 475301-73-6
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chlorophenyl)-2,2-Difluoroacetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment, supporting cGMP and ISO 9001 standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.