Description

2H-Pyrrole,3,4-Dihydro-3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-,1-Oxide,(3S)-(9Ci) is a high-purity, chiral pyrrolidine derivative of significant interest in advanced organic synthesis. Its value lies in its role as a versatile, protected intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in many active pharmaceutical ingredients. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel drug candidates, asymmetric synthesis, and the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug molecules, particularly those containing pyrrolidine or pyrrolidine N-oxide motifs.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce chirality into target molecules, crucial for developing enantiomerically pure therapeutics.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides with specific biological activity.
• Chemical Biology & Proteomics: Used in the design and synthesis of molecular probes and enzyme inhibitors for biological target validation.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects.
• Material Science: Potential precursor for specialty polymers or functionalized surfaces requiring specific nitrogen-based heterocycles.

Basic Information

Product Name	2H-Pyrrole,3,4-Dihydro-3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-,1-Oxide,(3S)-(9Ci)
CAS No.	474827-01-5
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	(3S)-3-[(Tetrahydro-2H-pyran-2-yl)oxy]-2,3-dihydro-1H-pyrrole 1-oxide; (3S)-3-(Tetrahydro-2H-pyran-2-yloxy)-3,4-dihydro-2H-pyrrole 1-oxide; 3,4-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyrrole 1-oxide, (3S)-; (S)-3-(Tetrahydro-2H-pyran-2-yloxy)-3,4-dihydro-2H-pyrrole 1-oxide; Pyrrolidine N-oxide derivative, THP-protected; Chiral pyrrolidine N-oxide intermediate; 474827-01-5
EINECS	Contact for details

Quality Control

Our 2H-Pyrrole,3,4-Dihydro-3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-,1-Oxide,(3S)-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.