Description

Methyl 6-Bromoquinazoline-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound serves as a crucial building block in the development of novel, biologically active molecules, particularly kinase inhibitors. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of targeted cancer therapies and other small-molecule drugs. The consistent quality and reliable supply of this intermediate are essential for streamlining complex multi-step synthesis in drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of quinazoline-based kinase inhibitors for oncology research and drug development.
• Chemical Synthesis Building Block: Used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex functionalities onto the quinazoline core.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• API Development: Serves as a critical intermediate in the scalable production of Active Pharmaceutical Ingredients (APIs) targeting EGFR, VEGFR, and other tyrosine kinases.
• Biochemical Tool Compound Synthesis: Used to create labeled or modified probes for biochemical and cellular assays in life science research.

Basic Information

Product Name	Methyl 6-Bromoquinazoline-4-Carboxylate
CAS No.	474710-78-6
Molecular Formula	C10H7BrN2O2
Molecular Weight	267.08 g/mol
Synonyms	6-Bromo-4-quinazolinecarboxylic acid methyl ester; Methyl 6-bromo-4-quinazolinecarboxylate; 6-Bromoquinazoline-4-carboxylic acid methyl ester; Quinazoline, 6-bromo-, 4-carboxylic acid methyl ester; Methyl 6-bromoquinoline-4-carboxylate (common misnomer); 474710-78-6; 6-Bromo-quinazoline-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 6-Bromoquinazoline-4-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Our quality commitment includes comprehensive identity, purity, and impurity profile analysis using techniques such as HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.