Description

(1R,3R)-1-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid CAS NO 474668-76-3 is a high-purity, chiral tetrahydro-β-carboline derivative, a crucial advanced pharmaceutical intermediate. This compound matters for its role as a sophisticated building block in the synthesis of complex bioactive molecules, particularly in neurological and psychiatric drug discovery. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for developing new therapeutic agents, where its defined stereochemistry and structural complexity are essential for achieving target specificity and efficacy.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and development of novel central nervous system (CNS) active drugs.
• Neurological Research: Used in the synthesis of potential therapeutic compounds targeting serotonin and other neurotransmitter receptors.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in the development of new catalytic and stoichiometric asymmetric synthetic methodologies due to its complex, rigid structure.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Tool Compound: Applied in in vitro assays to study enzyme inhibition or receptor binding mechanisms relevant to neuropharmacology.

Basic Information

Product Name	(1R,3R)-1-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid
CAS No.	474668-76-3
Molecular Formula	C21H18N2O4
Molecular Weight	362.38 g/mol
Synonyms	(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid; (1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid; Tetrahydro-β-carboline-3-carboxylic acid derivative; (R,R)-THBC derivative; Chiral THPI carboxylic acid; 1-(3,4-Methylenedioxyphenyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (specified isomer); BTD-THPI-COOH
EINECS	Contact for details

Quality Control

Our (1R,3R)-1-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay, to ensure compliance with research and pharmaceutical intermediate grade specifications. Comprehensive Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided to guarantee reproducible performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.