Description

(R)-1-(3,5-Difluorophenyl)Propan-1-Amine-Hcl CAS NO 473733-16-3 is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the development of new therapeutic agents and high-value chemical products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder treatments.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral catalysts and ligands used in asymmetric synthesis to induce high enantioselectivity in chemical reactions.
• Fine Chemical Manufacturing: Employed in the synthesis of complex, high-value specialty chemicals for electronics, materials science, and performance materials.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry optimization in both academic and corporate research laboratories.

Basic Information

Product Name	(R)-1-(3,5-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	473733-16-3
Molecular Formula	C9H11F2N•HCl
Molecular Weight	207.65 g/mol
Synonyms	(R)-1-(3,5-Difluorophenyl)propan-1-amine hydrochloride; (R)-3,5-Difluoro-α-methyl-benzenemethanamine hydrochloride; (R)-1-(3,5-Difluorophenyl)-1-propylamine HCl; (R)-3',5'-Difluoro-α-methylbenzylamine hydrochloride; (R)-1-Amino-1-(3,5-difluorophenyl)propane hydrochloride; (R)-3,5-Difluoroamphetamine hydrochloride; (R)-DFA HCl
EINECS	Contact for details

Quality Control

Our (R)-1-(3,5-Difluorophenyl)Propan-1-Amine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.