Description

(S)-3-Amino-2,2-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride is a high-purity, non-natural amino acid derivative featuring a chiral center and multiple fluorine substitutions. This compound matters as a sophisticated pharmaceutical intermediate and chiral building block critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology and metabolic diseases. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated motifs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of fluorinated protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Building block for novel, fluorinated pesticides and herbicides where the difluoro and aryl-fluoro groups can influence biological activity and environmental persistence.
• Peptidomimetics & Bio-conjugation: Used in the design of fluorinated peptide analogs and as a linker molecule in antibody-drug conjugates (ADCs) and other bioconjugates.
• Organofluorine Chemistry Research: A valuable substrate for studying the effects of gem-difluoro and aryl-fluoro substitutions on reaction mechanisms and physicochemical properties.
• Material Science Precursor: Potential monomer or additive for specialty polymers where fluorine content can impart unique surface properties and chemical resistance.

Basic Information

Product Name	(S)-3-Amino-2,2-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride
CAS No.	471931-01-8
Molecular Formula	C9H9ClF3NO2
Molecular Weight	255.62 g/mol
Synonyms	(S)-3-Amino-2,2-difluoro-3-(4-fluorophenyl)propanoic acid hydrochloride; (S)-2,2-Difluoro-3-amino-3-(4-fluorophenyl)propionic acid HCl; (S)-3-Amino-2,2-difluoro-3-(p-fluorophenyl)propionic acid hydrochloride; L-3-Amino-2,2-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride; (S)-α-Amino-β,β-difluoro-4-fluorohydrocinnamic acid hydrochloride; 471931-01-8; (S)-AADFPA-HCl
EINECS	Contact for details

Quality Control

Our (S)-3-Amino-2,2-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride is manufactured under cGMP-compliant conditions where applicable, ensuring traceability and batch-to-batch consistency. Quality is assured through a comprehensive battery of analytical tests including chiral HPLC for enantiomeric purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.