Description

L-Glutamic Acid, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl-, 1-(2-Propen-1-Yl) Ester is a specialized, high-purity amino acid derivative designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise building blocks for peptide synthesis and complex molecular construction. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected, side-chain activated glutamic acid derivative for the controlled incorporation of glutamic acid residues into peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, prodrugs, and targeted therapeutic molecules.
• Bioconjugation: The allyl ester protecting group and reactive side chain enable its use in site-specific protein and antibody modifications.
• Chemical Biology Probes: Acts as a precursor for synthesizing labeled amino acids or activity-based probes for studying enzyme function and metabolic pathways.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Essential for fundamental research in organic chemistry, medicinal chemistry, and biochemistry.

Basic Information

Product Name	L-Glutamic Acid, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl-, 1-(2-Propen-1-Yl) Ester
CAS No.	470681-45-9
Molecular Formula	C24H25NO6
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-N-Me-Glu(OAll)-OH; Fmoc-N-Methyl-L-glutamic acid 1-allyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-glutamic acid 1-(2-propen-1-yl) ester; N-Fmoc-N-methyl-L-glutamic acid γ-allyl ester; Fmoc-N-methylglutamic acid α-allyl ester; Nα-Fmoc-Nα-methyl-L-glutamic acid 1-allyl ester; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]pentanedioic acid 1-allyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.