Description

1,3-Dioxolane, 4-Ethynyl-2,2,5-Trimethyl-, (4R,5R)- (9Ci) is a high-purity, stereochemically defined chiral building block. This compound is valued for its unique molecular architecture, featuring a protected carbonyl equivalent and a reactive ethynyl group, making it a versatile intermediate in sophisticated organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular frameworks with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in catalytic processes.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science Research: Used in the development of novel polymers and advanced organic materials with tailored properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies and exploring new chemical transformations in laboratory settings.

Basic Information

Product Name	1,3-Dioxolane, 4-Ethynyl-2,2,5-Trimethyl-, (4R,5R)- (9Ci)
CAS No.	469903-96-6
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(4R,5R)-4-Ethynyl-2,2,5-trimethyl-1,3-dioxolane; (4R-cis)-4-Ethynyl-2,2,5-trimethyl-1,3-dioxolane; 4-Ethynyl-2,2,5-trimethyl-1,3-dioxolane, (4R,5R)-; (R,R)-4-Ethynyl-2,2,5-trimethyl-1,3-dioxolane; Chiral ethynyl dioxolane; Acetylene-functionalized dioxolane; 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)-
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane, 4-Ethynyl-2,2,5-Trimethyl-, (4R,5R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and storage should minimize exposure to light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.