Description

(S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine is a high-purity chiral amine building block featuring a nitrobenzenesulfonyl (nosyl) protecting group. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of complex, biologically active molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel drug candidates and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other targeted therapies.
• Peptidomimetic Chemistry: Used to introduce a chiral pyrrolidine scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral amine source or auxiliary in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Protecting Group Strategy: The 2-nitrobenzenesulfonyl (nosyl) group allows for selective protection and deprotection of the amine functionality during multi-step syntheses.
• Ligand and Catalyst Development: Utilized as a precursor for developing novel chiral ligands and organocatalysts.
• Agrochemical Research: Employed in the discovery and development of new chiral pesticides and herbicides.

Basic Information

Product Name	(S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine
CAS No.	468104-07-6
Molecular Formula	C10H13N3O4S
Molecular Weight	271.29 g/mol
Synonyms	(S)-3-Amino-1-(2-nitrobenzenesulfonyl)pyrrolidine; (S)-1-(2-Nitrobenzenesulfonyl)pyrrolidin-3-amine; (S)-1-(2-Nitrobenzenesulfonyl)-3-aminopyrrolidine; (S)-1-(2-Nitrophenylsulfonyl)pyrrolidin-3-amine; (S)-1-(o-Nitrobenzenesulfonyl)pyrrolidin-3-amine; (S)-1-(2-Nosyl)pyrrolidin-3-amine; (S)-3-Amino-1-(2-nosyl)pyrrolidine; (S)-Pyrrolidin-3-amine, 1-[(2-nitrophenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our (S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade research standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.