Description

(S)-Piperidin-2-Ylmethanol Hydrochloride CAS NO 459834-03-8 is a high-purity chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and functionalized piperidine core, which are critical for constructing molecules with specific biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in neurological and therapeutic agent research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Integral in the multi-step synthesis of complex, stereochemically pure Active Pharmaceutical Ingredients (APIs).
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring a defined (S)-configured piperidinemethanol moiety.
• Bioconjugation & Probe Synthesis: The functional groups allow for derivatization, useful in creating biochemical probes or tagged molecules for diagnostic applications.

Basic Information

Product Name	(S)-Piperidin-2-Ylmethanol Hydrochloride
CAS No.	459834-03-8
Molecular Formula	C6H14ClNO
Molecular Weight	151.64 g/mol
Synonyms	(S)-2-(Hydroxymethyl)piperidine hydrochloride; (S)-Piperidine-2-methanol hydrochloride; (2S)-2-Piperidinemethanol hydrochloride; (S)-(+)-2-Piperidinemethanol hydrochloride; (S)-2-Piperidinylmethanol hydrochloride; L-Pipecolinyl alcohol hydrochloride; (S)-(-)-2-Hydroxymethylpiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Piperidin-2-Ylmethanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.