Description

3-Chloro- L-Phenylalanine, Methyl Ester, Hydrochloride is a protected amino acid derivative, specifically a chlorinated phenylalanine methyl ester salt. This compound is a crucial chiral building block and intermediate in the synthesis of complex pharmaceutical molecules and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate a modified phenylalanine residue with specific steric and electronic properties.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Tool: Can be utilized in the study of enzyme mechanisms and as a substrate analog for chlorinating enzymes.
• Fine Chemical Synthesis: An intermediate for the preparation of more complex, high-value specialty chemicals and ligands for catalysis.

Basic Information

Product Name	3-Chloro- L-Phenylalanine, Methyl Ester, Hydrochloride
CAS No.	457654-76-1
Molecular Formula	C10H13Cl2NO2
Molecular Weight	250.12 g/mol
Synonyms	L-Phenylalanine, 3-chloro-, methyl ester, hydrochloride; Methyl (2S)-2-amino-3-(3-chlorophenyl)propanoate hydrochloride; (S)-Methyl 2-amino-3-(3-chlorophenyl)propanoate hydrochloride; 3-Chloro-L-phenylalanine methyl ester HCl; 3-Cl-Phe-OMe·HCl
EINECS	Contact for details

Quality Control

Our 3-Chloro- L-Phenylalanine, Methyl Ester, Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent decomposition. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.