Description

1-Naphthalenol, 1,2-Dihydro-2-Methyl-, (1S,2R)- (9Ci) is a chiral, substituted 1,2-dihydronaphthalene derivative that serves as a valuable synthetic intermediate in advanced organic chemistry. Its defined stereochemistry and functionalized naphthalene core make it a critical building block for the synthesis of complex, optically active molecules. This compound is primarily utilized by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its structural motif can contribute to biological activity.
• Material Science: Serves as a monomer or functional unit in the research of advanced polymers and liquid crystalline materials.
• Asymmetric Catalysis: Employed as a ligand precursor or a test substrate in the development and screening of new chiral catalysts.
• Academic & Industrial R&D: A versatile starting material for methodological studies in organic synthesis, including cycloaddition and functionalization reactions.

Basic Information

Product Name	1-Naphthalenol, 1,2-Dihydro-2-Methyl-, (1S,2R)- (9Ci)
CAS No.	457625-20-6
Molecular Formula	C₁₁H₁₂O
Molecular Weight	160.21 g/mol
Synonyms	(1S,2R)-2-Methyl-1,2-dihydro-1-naphthol; (1S,2R)-2-Methyl-1,2-dihydronaphthalen-1-ol; 1-Naphthalenol, 1,2-dihydro-2-methyl-, (1S,2R)-; (1S,2R)-1-Hydroxy-2-methyl-1,2-dihydronaphthalene; 2-Methyl-1,2-dihydronaphthalen-1-ol (enantiomer); Chiral dihydronaphthol derivative; (1S,2R)-rel-2-Methyl-1,2-dihydronaphthalen-1-ol
EINECS	Contact for details

Quality Control

We supply this chiral intermediate in high-purity grades suitable for demanding research and development applications. Our products undergo rigorous quality testing to ensure batch-to-batch consistency, with purity typically verified by chiral HPLC and ¹H/¹³C NMR. Certificates of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (e.e.), and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.