Description

2-Chloro-5-Fluoroquinoline is a high-purity, versatile fluorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an indispensable intermediate for developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinolone and fluoroquinolone-based antibiotics and other therapeutic agents.
• Agrochemical Research: Used in developing next-generation pesticides and herbicides, leveraging the bioactivity of the quinoline core.
• Material Science Precursor: Acts as a starting material for creating functionalized organic ligands and advanced organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the quinoline moiety into more complex molecules.
• Academic & Industrial R&D: Serves as a standard reagent in medicinal chemistry and process development laboratories for exploring new chemical entities.

Basic Information

Product Name	2-Chloro-5-Fluoroquinoline
CAS No.	455955-27-8
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	5-Fluoro-2-chloroquinoline; 2-Chloro-5-fluoroquinoline; Quinoline, 2-chloro-5-fluoro-; 455955-27-8; 2-Chlor-5-fluorchinolin (German); 2-クロロ-5-フルオロキノリン (Japanese)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong alkalis and fluorides. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.