Description

(S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-ring molecular architecture. This compound matters for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and antiviral research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for developing next-generation small molecule drugs where precise stereochemistry and functional group integration are paramount.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors.
• Oncology Drug Discovery: Used in the synthesis of experimental compounds targeting specific cancer pathways due to its naphthyridine and spirocyclic motifs.
• Antiviral Agent Synthesis: Serves as a building block for creating novel molecules with potential activity against viral enzymes.
• Biochemical Research: Employed in academic and industrial labs for structure-activity relationship (SAR) studies and medicinal chemistry optimization.
• Process Chemistry & Scale-Up: Used by CROs and CDMOs for developing and scaling synthetic routes from milligram to kilogram quantities.
• Reference Standard: Suitable for use as an analytical standard in quality control and method development for related drug substances.

Basic Information

Product Name	(S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate
CAS No.	455264-29-6
Molecular Formula	C30H32N4O3
Molecular Weight	496.60 g/mol
Synonyms	(S)-Ethyl 3-[4-[(2,7-naphthyridin-1-yl)amino]phenyl]-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]propanoate; UNII-6H0R4P8N8I; 1-Naphthyridine, 1-[[4-[(1S)-1-(ethoxycarbonyl)-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]ethyl]phenyl]amino]-; Ethyl (S)-3-(4-((2,7-naphthyridin-1-yl)amino)phenyl)-2-((3-oxospiro[3.5]non-1-en-1-yl)amino)propanoate; 6H0R4P8N8I; Propanoic acid, 3-[4-[(2,7-naphthyridin-1-yl)amino]phenyl]-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]-, ethyl ester, (S)-
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CMC sections).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.