Description

4H-1,3-Benzodioxin-6-Methanol, 2,2-Dimethyl-A-[[(Phenylmethyl)Amino]Methyl]-, (Ar)- is a specialized chiral organic compound featuring a benzodioxin core structure with a pendant amino alcohol functional group. This unique molecular architecture makes it a valuable building block and chiral intermediate for advanced chemical synthesis. It is primarily utilized by research institutions and industrial R&D departments engaged in the development of pharmaceuticals, agrochemicals, and fine chemicals, where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or cardiovascular targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the specific stereoisomer can influence efficacy and environmental profile.
• Catalyst and Ligand Development: Serves as a precursor for synthesizing chiral ligands used in asymmetric catalysis to create enantiomerically pure compounds.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex, high-value specialty chemicals for electronics, materials science, and diagnostics.
• Academic and Contract Research: A critical reagent for methodological studies in organic chemistry, particularly in exploring new asymmetric synthetic routes.

Basic Information

Product Name	4H-1,3-Benzodioxin-6-Methanol, 2,2-Dimethyl-A-[[(Phenylmethyl)Amino]Methyl]-, (Ar)-
CAS No.	452342-08-4
Molecular Formula	C20H25NO3
Molecular Weight	327.42 g/mol
Synonyms	(αR)-2,2-Dimethyl-α-[[(phenylmethyl)amino]methyl]-4H-1,3-benzodioxin-6-methanol; (R)-2,2-Dimethyl-α-((benzylamino)methyl)-4H-benzo[d][1,3]dioxine-6-methanol; (R)-6-(Hydroxymethyl)-2,2-dimethyl-N-benzyl-1,3-benzodioxin-4-amine; (R)-N-Benzyl-6-(hydroxymethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-amine; (R)-Tembamide derivative; Chiral Benzodioxin Amino Alcohol; (R)-enantiomer of CAS 452342-08-4.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is essential for downstream synthesis. Quality is verified through advanced analytical techniques including HPLC, chiral chromatography, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.