Description

Benzenesulfonamide, 4-Azido-3-Nitro- is a specialized aromatic sulfonamide derivative featuring both azido and nitro functional groups. This unique bifunctional structure makes it a valuable photoaffinity labeling agent and a versatile chemical building block for advanced synthesis. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and material scientists working on photoactive probes, polymer cross-linking, and the development of novel bioactive compounds.

Application

• Photoaffinity Labeling (PAL): A critical reagent in biochemical research for covalently tagging and identifying biological target proteins and binding sites upon photoactivation.
• Click Chemistry Synthesis: Serves as a key precursor or intermediate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for constructing complex molecular architectures.
• Polymer & Material Science: Used in the synthesis and modification of polymers, particularly for introducing cross-linking points or photo-responsive properties into materials.
• Pharmaceutical Intermediate: Employed in the research and development of novel drug candidates, especially those requiring targeted delivery or activity profiling mechanisms.
• Agrochemical Research: Acts as a synthetic intermediate in the design of new herbicides, pesticides, or plant growth regulators with specific modes of action.
• Proteomics & Chemical Biology: Integral to tool development for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.

Basic Information

Product Name	Benzenesulfonamide, 4-Azido-3-Nitro-
CAS No.	449790-50-5
Molecular Formula	C6H5N5O4S
Molecular Weight	243.20 g/mol
Synonyms	4-Azido-3-nitrobenzenesulfonamide; 3-Nitro-4-azidobenzenesulfonamide; Benzenesulfonamide, 4-azido-3-nitro-; NSC 339259; 4-Azido-3-nitrobenzene-1-sulfonamide; Azidobenzene sulfonamide derivative; Photoaffinity labeling reagent; PAL reagent
EINECS	Contact for details

Quality Control

Every batch of 4-Azido-3-Nitrobenzenesulfonamide is produced and controlled under a strict quality management system. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and the presence of an azide functional group, prolonged exposure to light, heat, or strong mechanical shock should be avoided. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.