Description

3-(2-Chloro-5-Fluoro-Phenyl)-Acrylic Acid is a high-value fluorinated aromatic acrylic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both chloro and fluoro substituents, makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and fungicides, where the fluorine atom enhances bioavailability and environmental stability.
• Material Science Research: Used in the development of specialty polymers and liquid crystal materials, leveraging its conjugated system for optoelectronic properties.
• Organic Synthesis: Versatile reagent for Heck reactions, cross-coupling, and other palladium-catalyzed transformations to introduce the (2-chloro-5-fluoro-phenyl)acryloyl moiety.
• Chemical Biology: Employed as a scaffold or linker in probe and inhibitor design for studying enzyme function and protein-ligand interactions.

Basic Information

Product Name	3-(2-Chloro-5-Fluoro-Phenyl)-Acrylic Acid
CAS No.	448193-92-8
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	(2E)-3-(2-Chloro-5-fluorophenyl)prop-2-enoic acid; trans-3-(2-Chloro-5-fluorophenyl)acrylic acid; 2-Chloro-5-fluorocinnamic acid; (E)-3-(2-Chloro-5-fluorophenyl)acrylic acid; 3-(2-Chloro-5-fluorophenyl)-2-propenoic acid; 2-Propenoic acid, 3-(2-chloro-5-fluorophenyl)-; 448193-92-8; CFPA
EINECS	Contact for details

Quality Control

Our production of 3-(2-Chloro-5-Fluoro-Phenyl)-Acrylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) against established internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.