Description

n-(2-Hydroxyethyl)-4-[(4-Oxo-3,5,6,7-Tetrahydro-4H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Sulfanyl]Butanamide is a high-purity, advanced pharmaceutical intermediate with the CAS number 446278-60-0. This compound is valued for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research and development teams and manufacturing units in the pharmaceutical and biotechnology sectors seeking to develop innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex heterocyclic drug candidates, particularly those targeting specific enzyme pathways.
• API Development: Serves as a core scaffold for the research and production of new Active Pharmaceutical Ingredients (APIs) with potential therapeutic applications.
• Biochemical Research: Used in life science research as a tool compound for studying biological mechanisms and structure-activity relationships (SAR).
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for use in custom synthesis and scale-up projects for clinical trial materials.
• Protease Inhibitor Research: May be employed in the development of inhibitors for specific protease enzymes, given its fused thienopyrimidine structure.
• Kinase Inhibitor Synthesis: Potential building block for creating novel kinase inhibitor libraries for drug discovery screening.

Basic Information

Product Name	n-(2-Hydroxyethyl)-4-[(4-Oxo-3,5,6,7-Tetrahydro-4H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Sulfanyl]Butanamide
CAS No.	446278-60-0
Molecular Formula	C15H19N3O3S2
Molecular Weight	353.46 g/mol
Synonyms	4-[(4-Oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio]-N-(2-hydroxyethyl)butanamide; 2-[(4-Oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio]-N-(2-hydroxyethyl)butyramide; 446278-60-0; Cyclopenta[4,5]thieno[2,3-d]pyrimidine derivative; Thienopyrimidine butanamide derivative.
EINECS	Contact for details

Quality Control

Our production of n-(2-Hydroxyethyl)-4-[(4-Oxo-3,5,6,7-Tetrahydro-4H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Sulfanyl]Butanamide adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and stored away from direct light and moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.