Description

Benzoic Acid, 4-(Difluoromethoxy)-3-Methoxy-, Hydrazide (9Ci) is a specialized aromatic hydrazide derivative, a high-value intermediate designed for advanced chemical synthesis. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and methoxy substitution pattern offers distinct reactivity and physicochemical properties. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors seeking to innovate and scale new molecular entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the difluoromethoxy group for improved activity and selectivity.
• Fine Chemical Synthesis: Used in custom and contract manufacturing for producing complex, high-value specialty chemicals and advanced materials.
• Chemical Biology & Proteomics: Employed as a reagent or linker in the development of chemical probes and activity-based protein profiling (ABPP) agents.
• Academic & Industrial R&D: Utilized in research laboratories for method development, structure-activity relationship (SAR) studies, and exploring new chemical spaces.

Basic Information

Product Name	Benzoic Acid, 4-(Difluoromethoxy)-3-Methoxy-, Hydrazide (9Ci)
CAS No.	446267-81-8
Molecular Formula	C9H10F2N2O3
Molecular Weight	232.19 g/mol
Synonyms	4-(Difluoromethoxy)-3-methoxybenzhydrazide; 3-Methoxy-4-(difluoromethoxy)benzoic acid hydrazide; 4-(Difluoromethoxy)-3-methoxybenzohydrazide; Benzoic acid, 4-(difluoromethoxy)-3-methoxy-, hydrazide; Benzhydrazide, 4-(difluoromethoxy)-3-methoxy-; 446267-81-8 (CAS); 4-(Difluoromethoxy)-3-methoxybenzoylhydrazine
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-(Difluoromethoxy)-3-Methoxy-, Hydrazide (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with complete batch-specific data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.