Description

Boc-2-Amino-5-Iodobenzoic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for constructing complex molecules, offering chemists precise control over molecular architecture. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted therapies and diagnostic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate iodinated aromatic amino acid residues with an N-terminal Boc-protecting group.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create biaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for imaging and biochemical assays due to its halogen atom.
• Agrochemical Research: Acts as an intermediate in the research and development of new herbicides and plant growth regulators.

Basic Information

Product Name	Boc-2-Amino-5-Iodobenzoic Acid
CAS No.	445479-86-7
Molecular Formula	C₁₂H₁₄INO₄
Molecular Weight	363.15 g/mol
Synonyms	5-Iodo-2-[(tert-butoxycarbonyl)amino]benzoic Acid; 2-[(tert-Butoxycarbonyl)amino]-5-iodobenzoic Acid; Boc-5-Iodoanthranilic Acid; tert-Butyl (5-iodo-2-carboxyphenyl)carbamate; N-Boc-2-Amino-5-iodobenzoic Acid; N-(tert-Butoxycarbonyl)-5-iodoanthranilic Acid; Boc-5-I-Abz-OH
EINECS	Contact for details

Quality Control

Every batch of Boc-2-Amino-5-Iodobenzoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.