Description

2-Methyl-n-(4-Methyl-2-Pyridinyl)-5-Oxo-7-Phenyl-4-[2-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarboxamide is a high-value, complex heterocyclic compound featuring a fused quinoline and pyridine core with a trifluoromethylphenyl substituent. This molecular architecture makes it a critical advanced pharmaceutical intermediate (API) for the research and development of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in developing small molecule drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Research & Development: Used in academic and industrial R&D for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Synthesis: The structural motifs suggest potential application in the development of protease or kinase inhibitors.
• Chemical Biology Probes: Utilized for creating specialized probes to study biological pathways and protein functions.
• Pre-clinical Development: Supports the synthesis of compounds required for pharmacological and toxicological evaluation.
• Custom Synthesis Projects: A critical substrate for custom and contract synthesis of complex, target-specific molecules.

Basic Information

Product Name	2-Methyl-n-(4-Methyl-2-Pyridinyl)-5-Oxo-7-Phenyl-4-[2-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarboxamide
CAS No.	445020-71-3
Molecular Formula	C31H26F3N3O2
Molecular Weight	529.55 g/mol
Synonyms	2-Methyl-N-(4-methylpyridin-2-yl)-5-oxo-7-phenyl-4-[2-(trifluoromethyl)phenyl]-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide; 4-[2-(Trifluoromethyl)phenyl]-2-methyl-N-(4-methyl-2-pyridinyl)-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide; Hexahydroquinolinecarboxamide derivative; CAS 445020-71-3; Trifluoromethylphenyl quinolinecarboxamide; Advanced Pharmaceutical Intermediate 445020-71-3
EINECS	Contact for details

Quality Control

Our production of this high-purity pharmaceutical intermediate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR, MS, and IR spectroscopy. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.