Description

2-Chloro-4-(2,2,2-trifluoroethoxy)phenol is a high-purity fluorinated phenolic compound, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular structure, which combines a halogenated phenol core with a trifluoroethoxy side chain, enabling precise chemical modifications. This product is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to build complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the trifluoroethoxy group can enhance lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Polymer Modification: Acts as a functional monomer or additive to introduce fluorine atoms into polymer chains, improving chemical resistance and surface properties.
• Organic Synthesis Research: A versatile reagent for constructing complex aromatic ethers and exploring new fluorination methodologies in academic and industrial R&D labs.

Basic Information

Product Name	2-Chloro-4-(2,2,2-trifluoroethoxy)phenol
CAS No.	444341-80-4
Molecular Formula	C8H6ClF3O2
Molecular Weight	226.58 g/mol
Synonyms	2-Chloro-4-(2,2,2-trifluoroethoxy)phenol; Phenol, 2-chloro-4-(2,2,2-trifluoroethoxy)-; 4-(2,2,2-Trifluoroethoxy)-2-chlorophenol; 2-Chloro-1-hydroxy-4-(2,2,2-trifluoroethoxy)benzene; 2-Chloro-4-(β,β,β-trifluoroethoxy)phenol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(2,2,2-trifluoroethoxy)phenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the stringent requirements for advanced intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.