Description

3,3'-[Dithiobis[(2S,4S)-4,2-Pyrrolidinediylcarbonylimino]]Bisbenzoic Acid Dihydrochloride is a sophisticated chiral organic compound featuring a disulfide bridge and a pyrrolidine-based scaffold, making it a valuable building block for advanced chemical synthesis. Its primary significance lies in its role as a key intermediate for the development of novel pharmaceutical agents, particularly in protease inhibitor research and targeted drug discovery. This high-purity compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on creating complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and synthesis of novel protease inhibitors and other therapeutic candidates.
• Peptidomimetic Research: Used to construct constrained peptide analogs and peptidomimetics due to its rigid, disulfide-linked bis-pyrrolidine structure.
• Bioconjugation Chemistry: Serves as a versatile linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of novel polymers with specific disulfide redox properties.

Basic Information

Item	Detail
Product Name	3,3'-[Dithiobis[(2S,4S)-4,2-Pyrrolidinediylcarbonylimino]]Bisbenzoic Acid Dihydrochloride
CAS No.	444057-64-1
Molecular Formula	C26H28N4O6S2 · 2HCl
Molecular Weight	621.53 g/mol
Synonyms	Bis(3-{[(2S,4S)-4-({[(3-Carboxyphenyl)amino]carbonyl})pyrrolidin-2-yl]disulfanyl}benzoic acid) dihydrochloride; (2S,2'S,4S,4'S)-2,2'-Disulfanediylbis(N-(3-carboxyphenyl)-4-carbamoylpyrrolidine-2-carboxamide) dihydrochloride; 3,3'-Disulfanediylbis[N-(3-carboxyphenyl)-L-prolinamide] dihydrochloride; Chiral Disulfide Pyrrolidine Bis-acid Dihydrochloride; CAS 444057-64-1
EINECS	Contact for details

Quality Control

Our 3,3'-[Dithiobis[(2S,4S)-4,2-Pyrrolidinediylcarbonylimino]]Bisbenzoic Acid Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support our global clientele in pharmaceutical and fine chemical sectors.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.