Description

[1,1'-Biphenyl]-4-Methanol, α-(Trifluoromethyl)- is a high-value fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the unique combination of a rigid biphenyl scaffold and a reactive benzylic alcohol group, further functionalized with a metabolically stable trifluoromethyl moiety. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules with enhanced biological activity and improved physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials in display and lighting technologies.
• Ligand & Catalyst Development: Employed in the creation of specialized chiral ligands and organocatalysts for asymmetric synthesis.
• Polymer & Material Science: Monomer for synthesizing high-performance, fluorinated polymers with unique thermal and chemical resistance.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, fragment-based drug discovery, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	[1,1'-Biphenyl]-4-Methanol, α-(Trifluoromethyl)-
CAS No.	438495-27-3
Molecular Formula	C14H11F3O
Molecular Weight	252.23 g/mol
Synonyms	4-(Trifluoromethyl)[1,1'-biphenyl]-4-methanol; α-(Trifluoromethyl)-[1,1'-biphenyl]-4-methanol; (4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-yl)methanol; 4'-(Trifluoromethyl)biphenyl-4-ylmethanol; 4-(Trifluoromethyl)-4'-hydroxymethylbiphenyl; Biphenyl-4-methanol, α-(trifluoromethyl)-; (4-(Trifluoromethyl)phenyl)phenylmethanol
EINECS	Contact for details

Quality Control

Our [1,1'-Biphenyl]-4-Methanol, α-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.