Description

Boc-Histidinol(Tos) CAS NO 438237-84-4 is a protected derivative of the amino acid histidine, specifically designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during multi-step synthetic processes. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and fine chemical suppliers engaged in the development of novel therapeutic peptides and peptidomimetics.

Application

• Key building block in the solid-phase and solution-phase synthesis of complex peptides containing histidine residues.
• Intermediate for the preparation of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Used in the research and development of enzyme inhibitors and receptor ligands where the imidazole side chain of histidine plays a crucial role.
• Essential reagent for constructing combinatorial libraries for high-throughput screening in drug discovery programs.
• Starting material for the synthesis of modified amino acids and specialized chiral auxiliaries.
• Applied in biochemical research for the study of metal-binding sites in proteins and enzymes.

Basic Information

Product Name	Boc-Histidinol(Tos)
CAS No.	438237-84-4
Molecular Formula	C18H27N3O5S
Molecular Weight	397.49 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-π-tosyl-L-histidinol; Boc-His(Tos)-ol; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[1-(4-methylphenyl)sulfonyl-1H-imidazol-4-yl]propan-1-ol; tert-Butyl N-[(1S)-1-(hydroxymethyl)-2-[1-(4-methylphenyl)sulfonylimidazol-4-yl]ethyl]carbamate; L-Histidinol, N2-[(1,1-dimethylethoxy)carbonyl]-N(pi)-[(4-methylphenyl)sulfonyl]-; Boc-L-Histidinol(Tosylate); Boc-His(Tos)-OH-ol; N-Boc-N'-Tosyl-L-histidinol
EINECS	Contact for details

Quality Control

Our Boc-Histidinol(Tos) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements, including those for GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.