Description

1-[(5-Bromothiophen-2-Yl)Sulfonyl]-4-(3-Chlorophenyl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct heterocyclic structure incorporating bromothiophene and chlorophenyl moieties. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and receptor-targeted drug discovery. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel targets.
• Chemical Biology Probe Development: Serves as a core scaffold for creating tool compounds to study biological pathways and protein function.
• Contract Synthesis: Supplied to CROs and CDMOs for custom synthesis projects and scale-up development.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	1-[(5-Bromothiophen-2-Yl)Sulfonyl]-4-(3-Chlorophenyl)Piperazine
CAS No.	438236-73-8
Molecular Formula	C15H14BrClN2O2S2
Molecular Weight	433.77 g/mol
Synonyms	4-(3-Chlorophenyl)-1-[(5-bromo-2-thienyl)sulfonyl]piperazine; 1-(5-Bromothiophene-2-sulfonyl)-4-(3-chlorophenyl)piperazine; 4-(3-Chlorophenyl)-1-(5-bromothiophene-2-sulfonyl)piperazine; 438236-73-8; 5-Bromo-2-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}thiophene
EINECS	Contact for details

Quality Control

Our 1-[(5-Bromothiophen-2-Yl)Sulfonyl]-4-(3-Chlorophenyl)Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.