Description

Benzyl 5-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic research laboratories focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting complex receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical spaces.
• Protease Inhibitor Synthesis: The spiro[indoline-3,4'-piperidine] core is a privileged scaffold found in inhibitors for various enzymes.
• Library Synthesis for High-Throughput Screening: Employed to create focused chemical libraries for biological screening against novel targets.
• CNS Drug Discovery: The structural motif is relevant for compounds interacting with neurological targets such as serotonin or dopamine receptors.
• Chemical Biology Probes: Useful for the development of tool compounds to study specific biological pathways and protein functions.

Basic Information

Product Name	Benzyl 5-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	438192-14-4
Molecular Formula	C20H19BrN2O2
Molecular Weight	399.28 g/mol
Synonyms	1'-Benzyloxycarbonyl-5-bromospiro[indoline-3,4'-piperidine]; Benzyl 5-bromo-1',2'-dihydrospiro[indoline-3,4'-piperidine]-1'-carboxylate; 5-Bromo-1'-(phenylmethoxy)carbonylspiro[1,3-dihydro-2H-indole-3,4'-piperidine]; 5-Bromospiro[indoline-3,4'-piperidine]-1'-carboxylic Acid Benzyl Ester; Cbz-5-Bromospiro[Indoline-3,4'-Piperidine]; 438192-14-4; 5-Bromo-1'-(benzyloxycarbonyl)spiro[indoline-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our Benzyl 5-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D, and we can support custom synthesis to meet specific project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.