Description

1-Amino-5-(2-Nitrobenzenesulfonamido)Pentane Hydrochloride is a specialized organic compound featuring a pentylamine linker with a nitrobenzenesulfonamide protecting group, presented as a stable hydrochloride salt. This compound is a critical intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive molecules where precise functional group manipulation is required. It is primarily sought by research institutions and chemical manufacturers engaged in peptide mimetics, drug discovery, and the synthesis of complex chemical libraries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Chemistry: Used in the preparation of peptide analogs and mimetics, often serving as a protected amine synthon.
• Protecting Group Strategy: The 2-nitrobenzenesulfonamide (Nosyl) group is a versatile protecting group for amines in multi-step organic synthesis.
• Bioconjugation: Potential use in linker chemistry for attaching payloads in antibody-drug conjugates (ADCs) or other bioconjugates.
• Chemical Research: Serves as a valuable reagent in academic and industrial R&D for exploring new synthetic methodologies.
• Agrochemical Synthesis: Intermediate in the development of new crop protection agents and herbicides.

Basic Information

Product Name	1-Amino-5-(2-Nitrobenzenesulfonamido)Pentane Hydrochloride
CAS No.	437718-20-2
Molecular Formula	C11H18N4O4S • HCl
Molecular Weight	338.81 g/mol
Synonyms	5-[(2-Nitrobenzenesulfonyl)amino]pentan-1-amine hydrochloride; 1,5-Pentanediamine, N1-(2-nitrobenzenesulfonyl)-, monohydrochloride; Nosyl-protected pentamethylenediamine hydrochloride; N1-(2-Nitrobenzenesulfonyl)-1,5-pentanediamine hydrochloride; 2-Nitro-N-(5-aminopentyl)benzenesulfonamide hydrochloride; N-(5-Aminopentyl)-2-nitrobenzenesulfonamide hydrochloride; Nosyl-PDA hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Amino-5-(2-Nitrobenzenesulfonamido)Pentane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.