Description

1-Chloro-5-Fluoroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is prized for its unique halogenated isoquinoline scaffold, which enables precise molecular modifications in the development of complex chemical entities. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Research: Serves as a versatile precursor in the synthesis of new-generation herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the synthesis of organic semiconductors, liquid crystals, and photoactive materials due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a molecular probe or a tagging reagent in bioconjugation and target identification studies.
• Cross-Coupling Reactions: Acts as an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to introduce the isoquinoline moiety.
• Nucleophilic Substitution: The chlorine atom at the 1-position is reactive towards various nucleophiles, enabling facile functionalization.

Basic Information

Product Name	1-Chloro-5-Fluoroisoquinoline
CAS No.	435278-02-7
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	5-Fluoro-1-chloroisoquinoline; 1-Chloro-5-fluoroisoquinoline; Isoquinoline, 1-chloro-5-fluoro-; 435278-02-7
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports applications in GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.