Description

3-(1H-Indol-3-Yl)-4-[2-(4-Methylpiperazin-1-Yl)Quinazolin-4-Yl]Pyrrole-2,5-Dione is a high-purity, heterocyclic organic compound designed for advanced research and development. This molecule is of significant interest as a key synthetic intermediate and a potential pharmacological scaffold in medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the discovery of novel therapeutic agents, particularly in oncology and kinase-related pathways.

Application

• Pharmaceutical Research & Development: Serves as a critical building block for synthesizing novel small-molecule drug candidates targeting specific enzymes and receptors.
• Kinase Inhibitor Development: Used as a core scaffold in the design and optimization of potent and selective kinase inhibitors due to its quinazoline and maleimide-like pyrrole-2,5-dione structure.
• Chemical Biology Probes: Employed in the creation of chemical probes to study protein function, signaling pathways, and target engagement in cellular assays.
• Medicinal Chemistry Libraries: A valuable component for constructing focused compound libraries for high-throughput screening (HTS) against diverse biological targets.
• Process Chemistry & Scale-up: Acts as an advanced intermediate in the development and optimization of scalable synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Academic Research: Supports fundamental studies in organic synthesis, heterocyclic chemistry, and structure-activity relationship (SAR) analysis.

Basic Information

Product Name	3-(1H-Indol-3-Yl)-4-[2-(4-Methylpiperazin-1-Yl)Quinazolin-4-Yl]Pyrrole-2,5-Dione
CAS No.	425637-18-9
Molecular Formula	C25H21N7O2
Molecular Weight	451.48 g/mol
Synonyms	3-(1H-Indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-1H-pyrrole-2,5-dione; 4-[2-(4-Methylpiperazin-1-yl)quinazolin-4-yl]-3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; 425637-18-9; 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione; 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-2,5-dihydro-1H-pyrrole-2,5-dione; 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-2,5-dihydro-1H-pyrrole-2,5-dione; 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our 3-(1H-Indol-3-Yl)-4-[2-(4-Methylpiperazin-1-Yl)Quinazolin-4-Yl]Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.