Description

5-(Methylnitrosamino)-1-(3-Pyridyl)-1-Pentanone is a nitrosamine compound of significant interest in analytical and regulatory chemistry. Its primary commercial value lies in its use as a certified reference material and analytical standard for quality control and safety testing. This compound is essential for laboratories and manufacturers in the pharmaceutical, tobacco, and food safety industries requiring precise detection and quantification of nitrosamine impurities. The CAS number for this substance is 424788-94-3.

Application

• Analytical Reference Standard: Primary use as a high-purity certified standard for calibrating equipment and validating analytical methods (e.g., HPLC, LC-MS/MS) for nitrosamine detection.
• Pharmaceutical Impurity Testing: Critical for compliance testing in active pharmaceutical ingredients (APIs) and finished drug products to meet stringent regulatory limits (e.g., EMA, FDA) for nitrosamine impurities.
• Tobacco and Smoke Research: Used in studies quantifying tobacco-specific nitrosamines (TSNAs) in tobacco products, smoke, and related environmental samples.
• Food and Beverage Safety Analysis: Employed in methods to detect and monitor nitrosamine contamination in processed foods, cured meats, and alcoholic beverages.
• Method Development and Validation: Serves as a key component in developing, optimizing, and accrediting new laboratory testing protocols for nitrosamines.
• Quality Control and Assurance: Provides an absolute benchmark for in-house QC laboratories to ensure the accuracy and reliability of their nitrosamine testing programs.
• Regulatory Compliance and Certification: Supports testing for global regulatory submissions and environmental monitoring to adhere to REACH, IARC, and other safety guidelines.

Basic Information

Product Name	5-(Methylnitrosamino)-1-(3-Pyridyl)-1-Pentanone
CAS No.	424788-94-3
Molecular Formula	C11H15N3O2
Molecular Weight	221.26 g/mol
Synonyms	NNK; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; N-Nitrosonornicotine ketone; Tobacco-specific nitrosamine NNK; (3-Pyridyl)-1-butanone, 4-(methylnitrosamino)-; 1-(3-Pyridyl)-1-butanone, 4-(methylnitrosamino)-; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridinyl)-1-butanone
EINECS	Contact for details

Quality Control

Every batch of 5-(Methylnitrosamino)-1-(3-Pyridyl)-1-Pentanone is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and stability of this critical reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from advanced techniques including HPLC, GC-MS, and NMR. Our quality protocols are designed to support compliance with pharmacopeial standards and Good Laboratory Practice (GLP).

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.