Description

Exo-3-Boc-3-Azabicyclo[3.1.0]Hexane-6-Methanol is a high-value, advanced pharmaceutical intermediate featuring a rigid, strained bicyclic scaffold. This compound matters as a sophisticated building block for medicinal chemistry, enabling the synthesis of novel drug candidates with complex three-dimensional architectures. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce constrained ring systems.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors for various protease targets.
• CNS Drug Discovery: Applied in the development of novel neuroactive compounds due to its bicyclic[3.1.0]hexane structure.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Exo-3-Boc-3-Azabicyclo[3.1.0]Hexane-6-Methanol
CAS No.	419572-18-2
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (exo); (1S,5R,6R)-6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester; exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol; tert-Butyl (1S,5R,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate; Bicyclo[3.1.0]hexane-6-methanol, 3-[(1,1-dimethylethoxy)carbonyl]-3-aza-, (1S,5R,6R)-; (exo)-3-Boc-3-azabicyclo[3.1.0]hexan-6-ylmethanol
EINECS	Contact for details

Quality Control

Our Exo-3-Boc-3-Azabicyclo[3.1.0]Hexane-6-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.